in , ,

All You Need To Know About Ziana For Acne

Ziana is a prescription treatment for acne for mild to severe cases. It is water-based, alcohol-free gel that you apply directly to your skin, on the whole area where you are breaking out.


This Ziana is a combination acne treatment, which means that it is a combination of two medication: antibiotic clindamycin, and topical retinoid tretinoin, commonly known as Retin-A. Ziana is only available by prescription so you need to see your dermatologist for evaluation and to get this treatment. You cannot buy it over-the-counter and there is no OTC alternative for this product.

How Ziana Treatment Works

Ziana is formulated with two active ingredients to fight acne in two particular ways: the Clindamycin and Tretinoin.

Clindamycin is an antibiotic that is known to treat acne. This ingredient minimizes the amount of acne-causing bacteria that is in the skin. These bacteria can also cause inflamed acne breakouts, although the bacteria is not the only factor that triggers the growth of acne. Some factors like clogged pores can also trigger the development of acne. And this is where the second active ingredient of Ziana comes in.

Tretinoin is commonly known as Retin-A. It is a derivative of vitamin A which speeds up the rate of cell turnovers. It keeps pores unclogged and eases existing comedones.

These two active ingredients are the keys for Ziana to be effective in fighting against inflammatory blemishes, like papules and pimples, and the non-inflammatory blackheads and whiteheads.

How to Use Ziana

ziana for acne
credit image: Facing Acne

Before using Ziana, read carefully the Patient Information Leaflet that is given by the pharmacist. Read again every time you get a refill. And if you have some doubts and questions, go back and consult your doctor.

Remember to wash your hands before applying this treatment. Gently clean the affected spot or skin with a mild or soapless cleanser. Pat dry. Use your fingertips to apply a small amount of Ziana, which is about the size of a pea, in a thin layer over your face. Do this once daily at bedtime, or as directed by your doctor. Avoid the eyes and lip areas.

  • Use this treatment on the skin only. Avoid applying it to the inner lip area or inside your nose or mouth. Never apply it to scraped, cut, sunburned, or eczema-affected skin.
  • Again, avoid applying Ziana in your eyes. If this happens, flush with huge amounts of water. Contact your doctor immediately when eye irritation occurs. Wash your hands immediately after using this treatment to avoid accidentally getting it in the eyes.

During the first several weeks of using Ziana, acne may appear worse because the treatment is working on your pimples that are forming inside your skin. It may take a few weeks to notice the results of this treatment.

Use this medication to get the best results. Remember to apply it at the same time every day. This will make you remember the method. Avoid using a huge amount, or use it more often than recommended. The skin will not improve faster but you are at high risks of experiencing peeling, pain, and redness of the skin.

And because Ziana is formulated to penetrate deep into your skin, this may harm an unborn baby and pregnant women, or who may become pregnant. They should avoid using this treatment.

If skin condition persists or worsen, consult your doctor immediately.

Potential Side Effects

Some possible side effects of using Ziana are:

  • Dryness
  • Skin irritation
  • Stinging or burning sensation
  • Peeling
  • Redness

Your doctor has given you this prescription treatment because he/she believes that the benefits of this medication are greater than the risks of side effects. Most people who use this medication did not experience severe side effects.

Again, consult your doctor immediately if you notice the following side effects:

  • Blistering
  • Severe burning or swelling of your skin
  • Crusting

Ziana may penetrate deep into your bloodstream and may rarely cause the serious intestinal condition (or Clostridium difficile-related diarrhea). This problem may happen a few weeks after the treatment has stopped. Avoid using any anti-diarrhea medication, or any narcotic pain relievers if you notice these side effects. That self-treatment may make your condition worse. Just consult your doctor immediately if you observe severe side effects, such as:

  • Persistent diarrhea
  • Blood or mucus in your stool
  • Abdominal or stomach pain or cramps

Some allergic reactions may also be experienced:

  • Itching or swelling on the face, tongue, or throat
  • Rashes
  • Severe dizziness
  • Trouble breathing

Consult your doctor immediately.

You may experience a change in skin color, like lightening or darkening of your skin. This is rare but a temporary side effect.

Avoid using Ziana if you have Crohn’s disease or ulcerative colitis, or if you have developed colitis with antibiotic use. Consult your doctor if you experience severe diarrhea. Inform your doctor is you are pregnant. If you are nursing a baby, inform your doctor also. Ziana may pass into breast milk and so, the doctor may advise you to wait until your baby is weaned before using Ziana. He/She may also recommend an acne treatment that is appropriate for breastfeeding mothers.

Other Useful Tips When Using Ziana

  • Apply sunscreen daily. Ziana may make your skin more sensitive to the sun. Avoid tanning or sunbathing also.
  • Protect your skin from extreme heat, cold, and wind to avoid extreme dry skin.
  • Avoid using drying toners or cleansers, scrubs, alcohol-based astringents or aftershaves, or any over-the-counter acne products.
  • When using Ziana, avoid applying it from the lips, eyes, and corners of the nose areas. These areas are very sensitive and can easily be irritated.

Always consult your doctor or dermatologist if you have any doubts or questions about your acne treatment.

What do you think?

Written by Maria

My passion is helping other people overcome the pain and embarrassment of acne. I have dealt with acne since my teenage years and know first-hand how hard it is to suffer from this condition.

Leave a Reply

GIPHY App Key not set. Please check settings

serums and oils

Difference Between Serums and Oils

clogged pores

Some Oils Are Not Good For Clogged Pores